We're pleased to announce the @ThePCCTC/@ANZUPtrials DASL – HiCaP study (Darolutamide Augments Standard Therapy for… https://t.co/ROHdKiEjEw
Expertise
Our Investigators
Internationally recognized leaders in the field, PCCTC investigators come from the nation’s top academic medical centers where they are actively engaged in innovative, multidisciplinary prostate cancer research. Leveraging their unique insights into the underlying biology of the disease, our investigators developed the universally adopted clinical states model of prostate cancer and initiated one of the first efforts in oncology to prospectively validate endpoints proposed in definitive phase III trials, PCWG2. The individual research objectives of our investigators are well represented in our clinical trial portfolio and unified by our translational, team-based approach to drug and biomarker development.
Drug Development
The PCCTC selects and prioritizes clinical development opportunities based on our investigators’ unparalleled understanding of the global clinical trials landscape, the strength of the underlying science, and the potential to address critical unmet needs across prostate cancer’s clinical spectrum. Our studies are characterized by close interaction between basic scientists and clinical investigators to optimize the flow of promising agents into early-phase studies, and the complimentary development of novel trial designs, endpoints and predictive biomarkers which ensure the decision to advance or to discontinue a program is made objectively and rapidly. The PCCTC’s Management Team and Scientific Oversight Committee work together to address the scientific, legal, regulatory, database, budgetary, and management concerns of every trial to further accelerate the development of successful drug candidates.
Biomarker Development
A cornerstone of the PCCTC’s research strategy is the co-development of therapies and biomarkers. To transform the clinical management of prostate cancer in the near term, it is essential to develop drugs in more precisely defined and biologically relevant patient groups. The ability to screen for patients most likely to respond to a novel agent is essential for both shortening development timelines and reducing exposure to unnecessary toxicity from ineffective treatment. Following the FDA’s Critical Path Initiative, we initiated one of the first endeavors in oncology to define blood and imaging-based biomarkers, develop analytically valid assays for them, and subsequently design and conduct the dedicated clinical trials necessary to establish their clinical validity. Capitalizing on the intellectual synergy of our investigators, our extensive clinical trial portfolio, and our many resources and basic science collaborations, our long-term objective is to establish intermediate or surrogate endpoints which can predict clinical benefit and form the basis for accelerated drug approvals.
Recent News +++
PCCTC trial is first to use standard Ra-223 doses, contemporary pain endpoints and PRO collection tools
Press Releases by PCCTC October 8, 2021 Learn MoreFirst-of-its-Kind Study Looks at Link Between Genes and Prostate Cancer
Press Releases by PCCTC August 26, 2021Researchers from Johns Hopkins University, University of Washington School of Medicine see...
Learn MorePCCTC Medical Director on the FDA Approval of Novel Prostate Cancer Imaging Tool
Press Releases by PCCTC May 27, 2021 Learn MoreTackling Diversity in Prostate Cancer Clinical Trials: A Report From the Diversity Working Group of the IRONMAN Registry
Press Releases by PCCTC April 16, 2021 Learn MoreBipolar Androgen Therapy for Patients Who Have Progressed on Abiraterone
Media Relations by PCCTC February 26, 2021Led by Dr. Samuel R. Denmeade and his team at Johns Hopkins School of Medicine – Sid...
Learn MorePCCTC Germline Genetics Working Group Publishes New Guidelines
Press Releases by PCCTC September 30, 2020Practical considerations and challenges for germline genetic testing in patients with pros...
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Join our team of dedicated clinical research professionals! The Prostate Cancer Clinical Trials Consortium is currently seeking a Quality Manager and Clinical Data Manager to help fulfill our…
2018-23944 Clinical Data Manager, Prostate Cancer Clinical Trials Consortium (PCCTC) | Memorial Sloan Kettering Cancer Center Careers
careers.mskcc.org
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