Expertise

Our Investigators

Internationally recognized leaders in the field, PCCTC investigators come from the nation’s top academic medical centers where they are actively engaged in innovative, multidisciplinary prostate cancer research. Leveraging their unique insights into the underlying biology of the disease, our investigators developed the universally adopted clinical states model of prostate cancer and initiated one of the first efforts in oncology to prospectively validate endpoints proposed in definitive phase III trials, PCWG2. The individual research objectives of our investigators are well represented in our clinical trial portfolio and unified by our translational, team-based approach to drug and biomarker development.

Drug Development

The PCCTC selects and prioritizes clinical development opportunities based on our investigators’ unparalleled understanding of the global clinical trials landscape, the strength of the underlying science, and the potential to address critical unmet needs across prostate cancer’s clinical spectrum. Our studies are characterized by close interaction between basic scientists and clinical investigators to optimize the flow of promising agents into early-phase studies, and the complimentary development of novel trial designs, endpoints and predictive biomarkers which ensure the decision to advance or to discontinue a program is made objectively and rapidly. The PCCTC’s Management Team and Scientific Oversight Committee work together to address the scientific, legal, regulatory, database, budgetary, and management concerns of every trial to further accelerate the development of successful drug candidates.

Biomarker Development

A cornerstone of the PCCTC’s research strategy is the co-development of therapies and biomarkers. To transform the clinical management of prostate cancer in the near term, it is essential to develop drugs in more precisely defined and biologically relevant patient groups. The ability to screen for patients most likely to respond to a novel agent is essential for both shortening development timelines and reducing exposure to unnecessary toxicity from ineffective treatment. Following the FDA’s Critical Path Initiative, we initiated one of the first endeavors in oncology to define blood and imaging-based biomarkers, develop analytically valid assays for them, and subsequently design and conduct the dedicated clinical trials necessary to establish their clinical validity. Capitalizing on the intellectual synergy of our investigators, our extensive clinical trial portfolio, and our many resources and basic science collaborations, our long-term objective is to establish intermediate or surrogate endpoints which can predict clinical benefit and form the basis for accelerated drug approvals.

Recent News +++

Phase I DSTP3086S Trial Results Published

Media Relations by PCCTC November 11, 2019

PCCTC study demonstrates safety and antitumor activity of humanized immunoglobulin G1 anti...

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PCCTC Investigators Drs. Rathkopf and McBride Receive Prestigious SU2C Grant

Press Releases by PCCTC October 17, 2019

Award will fund novel trial using immunotherapy combined with radiation and hormone therap...

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PCCTC Germline Genetics Working Group Publishes Results

Press Releases by PCCTC July 29, 2019

Study published in Clinical Genitourinary Cancer argues multidisciplinary efforts are key ...

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PCCTC Working Group Publishes Genetic Testing Manuscript

Press Releases by PCCTC April 26, 2019

Investigators from the Prostate Cancer Clinical Trials Consortium (PCCTC) formed the Germl...

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Phase III DORA Study Now Enrolling Patients with mCRPC

Press Releases by PCCTC April 19, 2019

The phase III DORA study (ClinicalTrials.gov Identifier: NCT03574571) led by PCCTC investi...

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Blood Test Predicts Resistance To Hormonal Therapy

Press Releases by MedPage Today March 18, 2019

AR-V7 successfully predicted resistance to hormonal therapy in advanced prostate cancer

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Great work on establishing the importance - but potentially distinct and complementary information - of CTCs and cf… https://t.co/g9JYGb6ZGw
@ThePCCTC ensures all stakeholders share responsibilities in development pathways, trial design, data evaluation, a… https://t.co/eo7z9bNX7p
RT @DoraTrial: 🇳🇱 @Franciscuszorg (PI = P. Hamberg, MD) is now enrolling patients to the #DORATrial (NCT03574571), a study to test Radium-2…

Join our team of dedicated clinical research professionals! The Prostate Cancer Clinical Trials Consortium is currently seeking a Quality Manager and Clinical Data Manager to help fulfill our…

2018-23944 Clinical Data Manager, Prostate Cancer Clinical Trials Consortium (PCCTC) | Memorial Sloan Kettering Cancer Center Careers

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