Studies

The PCCTC’s trial portfolio represents a substantial proportion of industry-sponsored and NIH-sponsored prostate cancer trials open in the US, characterizing a substantial presence in this research space. Our studies span the entire prostate cancer disease continuum and are strategically aligned with the Consortium’s own pathway-based scientific programs and a parallel commitment to the co-development of trial endpoints and biomarkers. Patient advocacy efforts are supported by Cancer ABCs.

Featured Studies

Phase III Trial of Docetaxel versus Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer

An International Registry for Men with Advanced Prostate Cancer

Our Active Study Portfolio

Prostate Cancer Outcomes: An International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN)

Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

A Phase II, Randomized, 2-Arm Study of Androgen Deprivation Therapy (ADT) Plus Apalutamide And Abiraterone Acetate (AAA) versus ADT + Abiraterone Acetate (ADT + A) in Patients with High Risk Localized, Regionally Metastatic, or Low-Volume Metastatic Non-Castrate Prostate Cancers

A Phase 2 Study of Cabazitaxel plus Carboplatin in men with metastatic castrate sensitive prostate cancer with and without DNA repair mutations (CASCARA)

A Single-arm, Phase 2 Study to Evaluate the Safety and Efficacy of IMMU-132 in Patients with CRPC Progressing on Enzalutamide or Abiraterone

A Phase Ib/II Study of Intermittent Talazoparib Plus Temozolomide in Subjects with mCRPC and No Mutations in DNA Damage Repair

The MAP Trial: Phase III Study of Muscadine plus (MPX) in Men with Prostate Cancer: A Randomized, Double-Blind, Placebo-Controlled Study of the Effects of MPX Capsules on Rising Prostate-Specific Antigen Levels in Alanine/Alanine SOD2 Genotype Men Following Initial Therapy for Prostate Cancer

A Phase 0 Study to Assess the Safety and Biodistribution of a Novel Radiolabeled Antibody Targeting Human Kallikrein-2 (hk2) in Subjects with mCRPC

Single Arm Phase II Study of Abiraterone + Atezolizumab + Lupron and Stereotactic Body Radiotherapy to the Prostate in Men with Newly Diagnosed Hormone-sensitive Metastatic Prostate Cancer

A Phase 2 Multicohort Study of Nivolumab in Combination with Docetaxel and Androgen Deprivation Therapy in Metastatic Hormone Sensitive Prostate Cancer Patients with DNA Damage Repair Defects or Inflamed Tumors

Randomized Phase IB/II Study of Enzalutamide With and Without Ribociclib in Patients With Metastatic Castrate Resistant, Chemotherapy Naïve Prostate Cancer That Retains RB Expression

BRCAAway: A Randomized Phase II Trial of Abiraterone, Olaparib, or Abiraterone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects

An Open-label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477 as Monotherapy and in Combination, in Patients With Advanced Solid/Metastatic Tumours

PROMISE: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness

DASL-HiCaP: Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate (ANZUP1801). A randomised phase 3 double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation in very high risk, clinically localised prostate cancer

A Phase 1/2 Study of EPI-7386 in Combination With Enzalutamide Compared With Enzalutamide Alone in Subjects With Metastatic Castration-Resistant Prostate Cancer

Recent News +++

The PCCTC at ASCO22

Press Releases by PCCTC June 3, 2022

More than 40,000 oncology professionals from around the world will convene at the annual A...

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Genetic Testing for Prostate Cancer: Considerations for Practice Virtual Genetics Board

Press Releases by PCCTC March 17, 2022

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Lantheus Collaborates with The Prostate Cancer Clinical Trial Consortium (PCCTC) To Advance AI-Enabled Imaging Biomarkers in Prostate Cancer

Press Releases by PCCTC January 27, 2022

NORTH BILLERICA, MA, January 27, 2022 – Lantheus Holdings, Inc. (NASDAQ: LNTH) (Lantheus...

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Genetic Testing for Prostate Cancer: Considerations for Practice Virtual Genetics Board

Press Releases by PCCTC December 8, 2021

The Prostate Cancer Clinical Trials Consortium (PCCTC) Genetics Germline Working Group is ...

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The PCCTC Seeks Director, Clinical Data Management & Informatics

Press Releases by PCCTC November 16, 2021

The Prostate Cancer Clinical Trials Consortium (PCCTC) was initiated in 2005 by the Prosta...

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PCCTC trial is first to use standard Ra-223 doses, contemporary pain endpoints and PRO collection tools

Press Releases by PCCTC October 8, 2021

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