Studies

The PCCTC’s trial portfolio represents a substantial proportion of industry-sponsored and NIH-sponsored prostate cancer trials open in the US, characterizing a substantial presence in this research space. Our studies span the entire prostate cancer disease continuum and are strategically aligned with the Consortium’s own pathway-based scientific programs and a parallel commitment to the co-development of trial endpoints and biomarkers. Patient advocacy efforts are supported by Cancer ABCs.

Featured Studies

Phase III Trial of Docetaxel versus Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer

An International Registry for Men with Advanced Prostate Cancer

PROMISE Registry: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness

Our Active Study Portfolio

Prostate Cancer Outcomes: An International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN)

Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

A Phase II, Randomized, 2-Arm Study of Androgen Deprivation Therapy (ADT) Plus Apalutamide And Abiraterone Acetate (AAA) versus ADT + Abiraterone Acetate (ADT + A) in Patients with High Risk Localized, Regionally Metastatic, or Low-Volume Metastatic Non-Castrate Prostate Cancers

A Single-arm, Phase 2 Study to Evaluate the Safety and Efficacy of IMMU-132 in Patients with CRPC Progressing on Enzalutamide or Abiraterone

A Phase Ib/II Study of Intermittent Talazoparib Plus Temozolomide in Subjects with mCRPC and No Mutations in DNA Damage Repair

A Phase 0 Study to Assess the Safety and Biodistribution of a Novel Radiolabeled Antibody Targeting Human Kallikrein-2 (hk2) in Subjects with mCRPC

Single Arm Phase II Study of Abiraterone + Atezolizumab + Lupron and Stereotactic Body Radiotherapy to the Prostate in Men with Newly Diagnosed Hormone-sensitive Metastatic Prostate Cancer

A Phase 2 Multicohort Study of Nivolumab in Combination with Docetaxel and Androgen Deprivation Therapy in Metastatic Hormone Sensitive Prostate Cancer Patients with DNA Damage Repair Defects or Inflamed Tumors

Randomized Phase IB/II Study of Enzalutamide With and Without Ribociclib in Patients With Metastatic Castrate Resistant, Chemotherapy Naïve Prostate Cancer That Retains RB Expression

BRCAAway: A Randomized Phase II Trial of Abiraterone, Olaparib, or Abiraterone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects

An Open-label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477 as Monotherapy and in Combination, in Patients With Advanced Solid/Metastatic Tumours

PROMISE: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness

DASL-HiCaP: Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate (ANZUP1801). A randomised phase 3 double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation in very high risk, clinically localised prostate cancer

A Phase 1/2 Study of EPI-7386 in Combination With Enzalutamide Compared With Enzalutamide Alone in Subjects With Metastatic Castration-Resistant Prostate Cancer

A Phase 1B Multiple Dose, Multiple-Arm, Parallel Assignment Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of XmAb®20717 Alone or in Combination with Chemotherapy or Targeted Therapies in Selected Subjects with Metastatic Castration Resistant Prostate Cancer

A Phase 1/2 Feasibility, Safety, And Activity Study of PSCA-Specific Chimeric Antigen Receptor Engineered T Cells (BPX-601) In Subjects with Previously Treated Advanced Solid Tumors

Recent News +++

PCCTC Study Finds Black Men with Metastatic Prostate Cancer May Benefit From Drug Combination

Media Relations by PCCTC June 2, 2023

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The PCCTC at ASCO23

Media Relations by PCCTC May 26, 2023

Fulfilling our mission of translating scientific discoveries to improved standards of care...

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Insights into Global Treatment Patterns for Advanced Prostate Cancer: The IRONMAN Registry

Media Relations by PCCTC May 10, 2023

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New Publication Highlights Therapies Advanced by the PCCTC within the Military Health System

Media Relations by PCCTC May 10, 2023

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The PCCTC Seeks Senior Cloud Engineer to Enhance Data Science

Media Relations by PCCTC April 25, 2023

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PCCTC Advocates Present Free Prostate Cancer Conference in Jersey City

Media Relations by PCCTC April 19, 2023

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Join our team of dedicated clinical research professionals! The Prostate Cancer Clinical Trials Consortium is currently seeking a Quality Manager and Clinical Data Manager to help fulfill our…

2018-23944 Clinical Data Manager, Prostate Cancer Clinical Trials Consortium (PCCTC) | Memorial Sloan Kettering Cancer Center Careers

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